Interventions / Treatment

Mortality and pulmonary outcomes of extremely preterm infants exposed to antenatal corticosteroids

ACOG & SMFM Updates Committee Opinion on Preterm Corticosteroids at 22 weeks

Antenatal Corticosteroid Therapy for Fetal Maturation

PPROM Prior to 33 0/7 Weeks: When Should Rescue Course Corticosteroids Be Given?

Repeat Antenatal Corticosteroids Decreased Neonatal Morbidity for Preterm Rupture of Membranes

Risk of Neonatal Sepsis with Rescue Steroids in Preterm Premature Rupture of Membranes versus Intact Membranes

Timing of corticosteroids for preterm premature rupture of membranes at 22 weeks: a decision analysis

Magnesium Sulfate Before Anticipated Preterm Birth for Neuroprotection

Effect of magnesium sulfate administration for neuroprotection on latency in women with preterm premature rupture of membranes

The use of antenatal magnesium sulfate for neuroprotection for infants born prematurely

Magnesium for Fetal Neuroprotection: Should it be Started When Delivery is Not Imminent in PPROM?

In the United States, each state determined their Neonatal Intensive Care Unit (NICU) levels, criteria, and qualifications.

For the purposes of Expectant Management in PPROM, it is extremely important to find a high acuity NICU that can take care of your baby. Not every hospital will have the right equipment and staff to manage an extremely preterm delivery complicated by PPROM.

We advise that you research hospitals to determine the following:

1. Does the hospital administer Nitric Oxide and Surfactant?

2. Is there a neonatologist on staff at all times?

3. Are there high-frequency ventilators (Jet & Oscillator) available on site?

4. If your baby needs to be transferred for more care, which hospital would be recommended?

Progesterone is not recommended in pregnancies complicated by PPROM. However, it may be beneficial to discuss with your medical provider for future pregnancies.

Progesterone can be administered orally, via suppository (rectal or vaginal), or via intramuscular injections.

Progesterone inhibits in vitro fetal membrane weakening

The choice of progestogen for the prevention of preterm birth in women with singleton pregnancy and prior preterm birth

Effects of progestogens in women with preterm premature rupture of membranes

Use of progesterone supplement therapy for prevention of preterm birth: review of literatures