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Chorioamnionitis & Sepsis

One of the largest risks of PPROM is the risk of infection. Chorioamnionitis and Sepsis are two of the most dangerous infections that women and their babies face in Expectant Management. There are many journals and studies detailing risks of infection -but it is our opinion that the information is not detailed, outdated, and does not effectively measure risks for PPROM in the different trimesters and gestational ages. 

With a ruptured amniotic sac, the risk of infection is very high - especially the first 72 hours and first week following PPROM. If you did not rupture due to an infection and are exercising Expectant Management, infection will always be a major concern. 

Signs of infection may be: temperature change, foul discharge, abdominal pain or pressure, cramping, etc. Notify your provider immediately if there are signs that may be concerning to you.  If an infection is suspected, delivery of the baby is the safest option to prevent maternal sepsis. While rare, cases of maternal demise from septic infections in PPROM have occurred.

Prolidase, Matrix Metalloproteinases 1 and 13 Activity, Oxidative-Antioxidative Status as a Marker of Preterm Premature Rupture of Membranes and Chorioamnionitis in Maternal Vaginal Washing Fluids (MMPs that play a role in collagen metabolism and increased oxidative stress may indicate amniochorion rupture and also may be etiologic factors for PPROM and chorioamniontis.)